Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis
Identifieur interne : 000009 ( Main/Exploration ); précédent : 000008; suivant : 000010Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis
Auteurs : Dandan Zhao ; Jing Wu ; Yinjuan Zhao ; Wei Shao ; Qi Cheng ; Xiaoyan Shao ; Xianwen Yuan ; Juan Ye ; Jianpu Gao ; Meiling Jin [République populaire de Chine] ; Chaojun Li ; Xiaolin Chen ; Yue Zhao ; Bin XueSource :
- Cancer Cell International [ 1475-2867 ] ; 2020.
Abstract
This study is to investigate the effects of zoledronic acid (ZA) on TSC2-null cell proliferation and on the tumor progression and recurrence in mouse models of lymphangioleiomyomatosis (LAM).
Subcutaneous mouse models and LAM mouse models were established. Immunohistochemistry and immunofluorescence were performed to detect the protein expression levels. TUNEL assay was conducted to detect cell apoptosis. Immunoprecipitation was carried out to determine the interaction between proteins.
ZA prevented the growth of TSC2-null cells both in culture and in LAM mouse models. Compared with rapamycin, ZA more effectively promoted the apoptosis of TSC2-null cells. Moreover, combined with the rapamycin, ZA effectively suppressed the tumor recurrence after drug withdrawal and ZA inhibited the activity of GTPase RhoA by decreasing protein geranylgeranylation, resulting in changes of Yap nucleus translocation.
ZA promotes cell apoptosis in TSC2-null cells through the RhoA/YAP signaling pathway. ZA may be used for the clinical treatment of LAM.
Url:
DOI: 10.1186/s12935-020-1131-4
PubMed: 32063747
PubMed Central: 7011352
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000052
- to stream Pmc, to step Curation: 000052
- to stream Pmc, to step Checkpoint: 000004
- to stream Ncbi, to step Merge: 000F32
- to stream Ncbi, to step Curation: 000F32
- to stream Ncbi, to step Checkpoint: 000F32
- to stream Main, to step Merge: 000009
- to stream Main, to step Curation: 000009
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis</title><author><name sortKey="Zhao, Dandan" sort="Zhao, Dandan" uniqKey="Zhao D" first="Dandan" last="Zhao">Dandan Zhao</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Wu, Jing" sort="Wu, Jing" uniqKey="Wu J" first="Jing" last="Wu">Jing Wu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Core Laboratory,</institution><institution>Sir Run Run Hospital, Nanjing Medical University,</institution></institution-wrap>Nanjing, 211166 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">211166 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Zhao, Yinjuan" sort="Zhao, Yinjuan" uniqKey="Zhao Y" first="Yinjuan" last="Zhao">Yinjuan Zhao</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.410625.4</institution-id><institution>Collaborative Innovation Center of Sustainable Forestry in Southern China, College of Forestry,</institution><institution>Nanjing Forestry University,</institution></institution-wrap>Nanjing, 210037 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210037 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Shao, Wei" sort="Shao, Wei" uniqKey="Shao W" first="Wei" last="Shao">Wei Shao</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Core Laboratory,</institution><institution>Sir Run Run Hospital, Nanjing Medical University,</institution></institution-wrap>Nanjing, 211166 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">211166 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Cheng, Qi" sort="Cheng, Qi" uniqKey="Cheng Q" first="Qi" last="Cheng">Qi Cheng</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Shao, Xiaoyan" sort="Shao, Xiaoyan" uniqKey="Shao X" first="Xiaoyan" last="Shao">Xiaoyan Shao</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Yuan, Xianwen" sort="Yuan, Xianwen" uniqKey="Yuan X" first="Xianwen" last="Yuan">Xianwen Yuan</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1800 1685</institution-id><institution-id institution-id-type="GRID">grid.428392.6</institution-id><institution>Department of Hepatobiliary Surgery,</institution><institution>The Affiliated Drum Tower Hospital of Nanjing University Medical School,</institution></institution-wrap>Nanjing, 210008 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210008 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Ye, Juan" sort="Ye, Juan" uniqKey="Ye J" first="Juan" last="Ye">Juan Ye</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1765 1045</institution-id><institution-id institution-id-type="GRID">grid.410745.3</institution-id><institution>Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine,</institution></institution-wrap>Nanjing, 210028 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210028 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Gao, Jianpu" sort="Gao, Jianpu" uniqKey="Gao J" first="Jianpu" last="Gao">Jianpu Gao</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Core Laboratory,</institution><institution>Sir Run Run Hospital, Nanjing Medical University,</institution></institution-wrap>Nanjing, 211166 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">211166 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Jin, Meiling" sort="Jin, Meiling" uniqKey="Jin M" first="Meiling" last="Jin">Meiling Jin</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1755 3939</institution-id><institution-id institution-id-type="GRID">grid.413087.9</institution-id><institution>Pulmonary Department,</institution><institution>Zhongshan Hospital, Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Li, Chaojun" sort="Li, Chaojun" uniqKey="Li C" first="Chaojun" last="Li">Chaojun Li</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Xiaolin" sort="Chen, Xiaolin" uniqKey="Chen X" first="Xiaolin" last="Chen">Xiaolin Chen</name><affiliation><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Respiratory Department,</institution><institution>Sir Run Run Hospital, Nanjing Medical University,</institution></institution-wrap>Nanjing, 211166 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">211166 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Zhao, Yue" sort="Zhao, Yue" uniqKey="Zhao Y" first="Yue" last="Zhao">Yue Zhao</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Xue, Bin" sort="Xue, Bin" uniqKey="Xue B" first="Bin" last="Xue">Bin Xue</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Core Laboratory,</institution><institution>Sir Run Run Hospital, Nanjing Medical University,</institution></institution-wrap>Nanjing, 211166 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">211166 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9776 7793</institution-id><institution-id institution-id-type="GRID">grid.254147.1</institution-id><institution>State Key Laboratory of Natural Medicines,</institution><institution>China Pharmaceutical University,</institution></institution-wrap>Nanjing, 210009 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210009 Jiangsu China</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">32063747</idno><idno type="pmc">7011352</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011352</idno><idno type="RBID">PMC:7011352</idno><idno type="doi">10.1186/s12935-020-1131-4</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000052</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000052</idno><idno type="wicri:Area/Pmc/Curation">000052</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000052</idno><idno type="wicri:Area/Pmc/Checkpoint">000004</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000004</idno><idno type="wicri:Area/Ncbi/Merge">000F32</idno><idno type="wicri:Area/Ncbi/Curation">000F32</idno><idno type="wicri:Area/Ncbi/Checkpoint">000F32</idno><idno type="wicri:Area/Main/Merge">000009</idno><idno type="wicri:Area/Main/Curation">000009</idno><idno type="wicri:Area/Main/Exploration">000009</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis</title><author><name sortKey="Zhao, Dandan" sort="Zhao, Dandan" uniqKey="Zhao D" first="Dandan" last="Zhao">Dandan Zhao</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Wu, Jing" sort="Wu, Jing" uniqKey="Wu J" first="Jing" last="Wu">Jing Wu</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Core Laboratory,</institution><institution>Sir Run Run Hospital, Nanjing Medical University,</institution></institution-wrap>Nanjing, 211166 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">211166 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Zhao, Yinjuan" sort="Zhao, Yinjuan" uniqKey="Zhao Y" first="Yinjuan" last="Zhao">Yinjuan Zhao</name><affiliation><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.410625.4</institution-id><institution>Collaborative Innovation Center of Sustainable Forestry in Southern China, College of Forestry,</institution><institution>Nanjing Forestry University,</institution></institution-wrap>Nanjing, 210037 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210037 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Shao, Wei" sort="Shao, Wei" uniqKey="Shao W" first="Wei" last="Shao">Wei Shao</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Core Laboratory,</institution><institution>Sir Run Run Hospital, Nanjing Medical University,</institution></institution-wrap>Nanjing, 211166 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">211166 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Cheng, Qi" sort="Cheng, Qi" uniqKey="Cheng Q" first="Qi" last="Cheng">Qi Cheng</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Shao, Xiaoyan" sort="Shao, Xiaoyan" uniqKey="Shao X" first="Xiaoyan" last="Shao">Xiaoyan Shao</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Yuan, Xianwen" sort="Yuan, Xianwen" uniqKey="Yuan X" first="Xianwen" last="Yuan">Xianwen Yuan</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1800 1685</institution-id><institution-id institution-id-type="GRID">grid.428392.6</institution-id><institution>Department of Hepatobiliary Surgery,</institution><institution>The Affiliated Drum Tower Hospital of Nanjing University Medical School,</institution></institution-wrap>Nanjing, 210008 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210008 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Ye, Juan" sort="Ye, Juan" uniqKey="Ye J" first="Juan" last="Ye">Juan Ye</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1765 1045</institution-id><institution-id institution-id-type="GRID">grid.410745.3</institution-id><institution>Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine,</institution></institution-wrap>Nanjing, 210028 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210028 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Gao, Jianpu" sort="Gao, Jianpu" uniqKey="Gao J" first="Jianpu" last="Gao">Jianpu Gao</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Core Laboratory,</institution><institution>Sir Run Run Hospital, Nanjing Medical University,</institution></institution-wrap>Nanjing, 211166 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">211166 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Jin, Meiling" sort="Jin, Meiling" uniqKey="Jin M" first="Meiling" last="Jin">Meiling Jin</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1755 3939</institution-id><institution-id institution-id-type="GRID">grid.413087.9</institution-id><institution>Pulmonary Department,</institution><institution>Zhongshan Hospital, Fudan University,</institution></institution-wrap>Shanghai, 200032 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai</wicri:regionArea></affiliation></author><author><name sortKey="Li, Chaojun" sort="Li, Chaojun" uniqKey="Li C" first="Chaojun" last="Li">Chaojun Li</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Chen, Xiaolin" sort="Chen, Xiaolin" uniqKey="Chen X" first="Xiaolin" last="Chen">Xiaolin Chen</name><affiliation><nlm:aff id="Aff9"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Respiratory Department,</institution><institution>Sir Run Run Hospital, Nanjing Medical University,</institution></institution-wrap>Nanjing, 211166 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">211166 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Zhao, Yue" sort="Zhao, Yue" uniqKey="Zhao Y" first="Yue" last="Zhao">Yue Zhao</name><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation></author><author><name sortKey="Xue, Bin" sort="Xue, Bin" uniqKey="Xue B" first="Bin" last="Xue">Bin Xue</name><affiliation><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9255 8984</institution-id><institution-id institution-id-type="GRID">grid.89957.3a</institution-id><institution>Core Laboratory,</institution><institution>Sir Run Run Hospital, Nanjing Medical University,</institution></institution-wrap>Nanjing, 211166 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">211166 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>State Key Laboratory of Pharmaceutical Biotechnology, Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff7"><institution-wrap><institution-id institution-id-type="ISNI">0000 0001 2314 964X</institution-id><institution-id institution-id-type="GRID">grid.41156.37</institution-id><institution>Jiangsu Key Laboratory of Molecular Medicine and School of Medicine,</institution><institution>Nanjing University,</institution></institution-wrap>Nanjing, 210093 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210093 Jiangsu China</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff8"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9776 7793</institution-id><institution-id institution-id-type="GRID">grid.254147.1</institution-id><institution>State Key Laboratory of Natural Medicines,</institution><institution>China Pharmaceutical University,</institution></institution-wrap>Nanjing, 210009 Jiangsu China</nlm:aff><wicri:noCountry code="subfield">210009 Jiangsu China</wicri:noCountry></affiliation></author></analytic><series><title level="j">Cancer Cell International</title><idno type="eISSN">1475-2867</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p id="Par1">This study is to investigate the effects of zoledronic acid (ZA) on TSC2-null cell proliferation and on the tumor progression and recurrence in mouse models of lymphangioleiomyomatosis (LAM).</p></sec><sec><title>Methods</title><p id="Par2">Subcutaneous mouse models and LAM mouse models were established. Immunohistochemistry and immunofluorescence were performed to detect the protein expression levels. TUNEL assay was conducted to detect cell apoptosis. Immunoprecipitation was carried out to determine the interaction between proteins.</p></sec><sec><title>Results</title><p id="Par3">ZA prevented the growth of TSC2-null cells both in culture and in LAM mouse models. Compared with rapamycin, ZA more effectively promoted the apoptosis of TSC2-null cells. Moreover, combined with the rapamycin, ZA effectively suppressed the tumor recurrence after drug withdrawal and ZA inhibited the activity of GTPase RhoA by decreasing protein geranylgeranylation, resulting in changes of Yap nucleus translocation.</p></sec><sec><title>Conclusion</title><p id="Par4">ZA promotes cell apoptosis in TSC2-null cells through the RhoA/YAP signaling pathway. ZA may be used for the clinical treatment of LAM.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Atochina Vasserman, En" uniqKey="Atochina Vasserman E">EN Atochina-Vasserman</name></author><author><name sortKey="Guo, C J" uniqKey="Guo C">C-J Guo</name></author><author><name sortKey="Abramova, E" uniqKey="Abramova E">E Abramova</name></author><author><name sortKey="Golden, Tn" uniqKey="Golden T">TN Golden</name></author><author><name sortKey="Sims, M" uniqKey="Sims M">M Sims</name></author><author><name sortKey="James, Ml" uniqKey="James M">ML James</name></author><author><name sortKey="Beers, Mf" uniqKey="Beers M">MF Beers</name></author><author><name sortKey="Gow, Aj" uniqKey="Gow A">AJ Gow</name></author><author><name sortKey="Krymskaya, Vp" uniqKey="Krymskaya V">VP Krymskaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baldi, Bg" uniqKey="Baldi B">BG Baldi</name></author><author><name sortKey="Freitas, Csg" uniqKey="Freitas C">CSG Freitas</name></author><author><name sortKey="Araujo, Ms" uniqKey="Araujo M">MS Araujo</name></author><author><name sortKey="Dias, Om" uniqKey="Dias O">OM Dias</name></author><author><name sortKey="Pereira, Das" uniqKey="Pereira D">DAS Pereira</name></author><author><name sortKey="Pimenta, Sp" uniqKey="Pimenta S">SP Pimenta</name></author><author><name sortKey="Kairalla, Ra" uniqKey="Kairalla R">RA Kairalla</name></author><author><name sortKey="Carvalho, Crr" uniqKey="Carvalho C">CRR Carvalho</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Costello, Lc" uniqKey="Costello L">LC Costello</name></author><author><name sortKey="Hartman, Te" uniqKey="Hartman T">TE Hartman</name></author><author><name sortKey="Ryu, Jh" uniqKey="Ryu J">JH Ryu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farach, Ls" uniqKey="Farach L">LS Farach</name></author><author><name sortKey="Pearson, Da" uniqKey="Pearson D">DA Pearson</name></author><author><name sortKey="Woodhouse, Jp" uniqKey="Woodhouse J">JP Woodhouse</name></author><author><name sortKey="Schraw, Jm" uniqKey="Schraw J">JM Schraw</name></author><author><name sortKey="Sahin, M" uniqKey="Sahin M">M Sahin</name></author><author><name sortKey="Krueger, Da" uniqKey="Krueger D">DA Krueger</name></author><author><name sortKey="Wu, Jy" uniqKey="Wu J">JY Wu</name></author><author><name sortKey="Bebin, Em" uniqKey="Bebin E">EM Bebin</name></author><author><name sortKey="Lupo, Pj" uniqKey="Lupo P">PJ Lupo</name></author><author><name sortKey="Au, Ks" uniqKey="Au K">KS Au</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Atochina Vasserman, En" uniqKey="Atochina Vasserman E">EN Atochina-Vasserman</name></author><author><name sortKey="Abramova, E" uniqKey="Abramova E">E Abramova</name></author><author><name sortKey="James, Ml" uniqKey="James M">ML James</name></author><author><name sortKey="Rue, R" uniqKey="Rue R">R Rue</name></author><author><name sortKey="Liu, Ay" uniqKey="Liu A">AY Liu</name></author><author><name sortKey="Ersumo, Nt" uniqKey="Ersumo N">NT Ersumo</name></author><author><name sortKey="Guo, C J" uniqKey="Guo C">C-J Guo</name></author><author><name sortKey="Gow, Aj" uniqKey="Gow A">AJ Gow</name></author><author><name sortKey="Krymskaya, Vp" uniqKey="Krymskaya V">VP Krymskaya</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glasgow, Cg" uniqKey="Glasgow C">CG Glasgow</name></author><author><name sortKey="Pacheco Rodriguez, G" uniqKey="Pacheco Rodriguez G">G Pacheco-Rodriguez</name></author><author><name sortKey="Steagall, Wk" uniqKey="Steagall W">WK Steagall</name></author><author><name sortKey="Haughey, Me" uniqKey="Haughey M">ME Haughey</name></author><author><name sortKey="Julien Williams, Pa" uniqKey="Julien Williams P">PA Julien-Williams</name></author><author><name sortKey="Stylianou, Mp" uniqKey="Stylianou M">MP Stylianou</name></author><author><name sortKey="Gochuico, Br" uniqKey="Gochuico B">BR Gochuico</name></author><author><name sortKey="Moss, J" uniqKey="Moss J">J Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meraj, R" uniqKey="Meraj R">R Meraj</name></author><author><name sortKey="Wikenheiser Brokamp, Ka" uniqKey="Wikenheiser Brokamp K">KA Wikenheiser-Brokamp</name></author><author><name sortKey="Young, Lr" uniqKey="Young L">LR Young</name></author><author><name sortKey="Mccormack, Fx" uniqKey="Mccormack F">FX McCormack</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muzykewicz, Da" uniqKey="Muzykewicz D">DA Muzykewicz</name></author><author><name sortKey="Sharma, A" uniqKey="Sharma A">A Sharma</name></author><author><name sortKey="Muse, V" uniqKey="Muse V">V Muse</name></author><author><name sortKey="Numis, Al" uniqKey="Numis A">AL Numis</name></author><author><name sortKey="Rajagopal, J" uniqKey="Rajagopal J">J Rajagopal</name></author><author><name sortKey="Thiele, Ea" uniqKey="Thiele E">EA Thiele</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Carsillo, T" uniqKey="Carsillo T">T Carsillo</name></author><author><name sortKey="Astrinidis, A" uniqKey="Astrinidis A">A Astrinidis</name></author><author><name sortKey="Henske, Ep" uniqKey="Henske E">EP Henske</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Inoki, K" uniqKey="Inoki K">K Inoki</name></author><author><name sortKey="Li, Y" uniqKey="Li Y">Y Li</name></author><author><name sortKey="Xu, T" uniqKey="Xu T">T Xu</name></author><author><name sortKey="Guan, K L" uniqKey="Guan K">K-L Guan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tyryshkin, A" uniqKey="Tyryshkin A">A Tyryshkin</name></author><author><name sortKey="Bhattacharya, A" uniqKey="Bhattacharya A">A Bhattacharya</name></author><author><name sortKey="Eissa, Nt" uniqKey="Eissa N">NT Eissa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Slomovitz, Bm" uniqKey="Slomovitz B">BM Slomovitz</name></author><author><name sortKey="Coleman, Rl" uniqKey="Coleman R">RL Coleman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Chemaly, S" uniqKey="El Chemaly S">S El-Chemaly</name></author><author><name sortKey="Taveira Dasilva, A" uniqKey="Taveira Dasilva A">A Taveira-Dasilva</name></author><author><name sortKey="Goldberg, Hj" uniqKey="Goldberg H">HJ Goldberg</name></author><author><name sortKey="Peters, E" uniqKey="Peters E">E Peters</name></author><author><name sortKey="Haughey, M" uniqKey="Haughey M">M Haughey</name></author><author><name sortKey="Bienfang, D" uniqKey="Bienfang D">D Bienfang</name></author><author><name sortKey="Jones, Am" uniqKey="Jones A">AM Jones</name></author><author><name sortKey="Julien Williams, P" uniqKey="Julien Williams P">P Julien-Williams</name></author><author><name sortKey="Cui, Y" uniqKey="Cui Y">Y Cui</name></author><author><name sortKey="Villalba, Ja" uniqKey="Villalba J">JA Villalba</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Davies, Dm" uniqKey="Davies D">DM Davies</name></author><author><name sortKey="Johnson, Sr" uniqKey="Johnson S">SR Johnson</name></author><author><name sortKey="Tattersfield, Ae" uniqKey="Tattersfield A">AE Tattersfield</name></author><author><name sortKey="Kingswood, Jc" uniqKey="Kingswood J">JC Kingswood</name></author><author><name sortKey="Cox, Ja" uniqKey="Cox J">JA Cox</name></author><author><name sortKey="Mccartney, Dl" uniqKey="Mccartney D">DL McCartney</name></author><author><name sortKey="Doyle, T" uniqKey="Doyle T">T Doyle</name></author><author><name sortKey="Elmslie, F" uniqKey="Elmslie F">F Elmslie</name></author><author><name sortKey="Saggar, A" uniqKey="Saggar A">A Saggar</name></author><author><name sortKey="De Vries, Pj" uniqKey="De Vries P">PJ de Vries</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mccormack, Fx" uniqKey="Mccormack F">FX McCormack</name></author><author><name sortKey="Inoue, Y" uniqKey="Inoue Y">Y Inoue</name></author><author><name sortKey="Moss, J" uniqKey="Moss J">J Moss</name></author><author><name sortKey="Singer, Lg" uniqKey="Singer L">LG Singer</name></author><author><name sortKey="Strange, C" uniqKey="Strange C">C Strange</name></author><author><name sortKey="Nakata, K" uniqKey="Nakata K">K Nakata</name></author><author><name sortKey="Barker, Af" uniqKey="Barker A">AF Barker</name></author><author><name sortKey="Chapman, Jt" uniqKey="Chapman J">JT Chapman</name></author><author><name sortKey="Brantly, Ml" uniqKey="Brantly M">ML Brantly</name></author><author><name sortKey="Stocks, Jm" uniqKey="Stocks J">JM Stocks</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taveira Dasilva, Am" uniqKey="Taveira Dasilva A">AM Taveira-DaSilva</name></author><author><name sortKey="Hathaway, O" uniqKey="Hathaway O">O Hathaway</name></author><author><name sortKey="Stylianou, M" uniqKey="Stylianou M">M Stylianou</name></author><author><name sortKey="Moss, J" uniqKey="Moss J">J Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feldman, Me" uniqKey="Feldman M">ME Feldman</name></author><author><name sortKey="Apsel, B" uniqKey="Apsel B">B Apsel</name></author><author><name sortKey="Uotila, A" uniqKey="Uotila A">A Uotila</name></author><author><name sortKey="Loewith, R" uniqKey="Loewith R">R Loewith</name></author><author><name sortKey="Knight, Za" uniqKey="Knight Z">ZA Knight</name></author><author><name sortKey="Ruggero, D" uniqKey="Ruggero D">D Ruggero</name></author><author><name sortKey="Shokat, Km" uniqKey="Shokat K">KM Shokat</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mullen, Pj" uniqKey="Mullen P">PJ Mullen</name></author><author><name sortKey="Yu, R" uniqKey="Yu R">R Yu</name></author><author><name sortKey="Longo, J" uniqKey="Longo J">J Longo</name></author><author><name sortKey="Archer, Mc" uniqKey="Archer M">MC Archer</name></author><author><name sortKey="Penn, Lz" uniqKey="Penn L">LZ Penn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luckman, Sp" uniqKey="Luckman S">SP Luckman</name></author><author><name sortKey="Hughes, De" uniqKey="Hughes D">DE Hughes</name></author><author><name sortKey="Coxon, Fp" uniqKey="Coxon F">FP Coxon</name></author><author><name sortKey="Russell, Rgg" uniqKey="Russell R">RGG Russell</name></author><author><name sortKey="Rogers, Mj" uniqKey="Rogers M">MJ Rogers</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goldstein, Jl" uniqKey="Goldstein J">JL Goldstein</name></author><author><name sortKey="Brown, Ms" uniqKey="Brown M">MS Brown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taveira Dasilva, Am" uniqKey="Taveira Dasilva A">AM Taveira-DaSilva</name></author><author><name sortKey="Jones, Am" uniqKey="Jones A">AM Jones</name></author><author><name sortKey="Julien Williams, Pa" uniqKey="Julien Williams P">PA Julien-Williams</name></author><author><name sortKey="Stylianou, M" uniqKey="Stylianou M">M Stylianou</name></author><author><name sortKey="Moss, J" uniqKey="Moss J">J Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taveira Dasilva, Am" uniqKey="Taveira Dasilva A">AM Taveira-DaSilva</name></author><author><name sortKey="Jones, Am" uniqKey="Jones A">AM Jones</name></author><author><name sortKey="Julien Williams, P" uniqKey="Julien Williams P">P Julien-Williams</name></author><author><name sortKey="Stylianou, M" uniqKey="Stylianou M">M Stylianou</name></author><author><name sortKey="Moss, J" uniqKey="Moss J">J Moss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sunaga, T" uniqKey="Sunaga T">T Sunaga</name></author><author><name sortKey="Shimamoto, K" uniqKey="Shimamoto K">K Shimamoto</name></author><author><name sortKey="Nakamura, S" uniqKey="Nakamura S">S Nakamura</name></author><author><name sortKey="Takahashi, N" uniqKey="Takahashi N">N Takahashi</name></author><author><name sortKey="Higashino, M" uniqKey="Higashino M">M Higashino</name></author><author><name sortKey="Hozumi, T" uniqKey="Hozumi T">T Hozumi</name></author><author><name sortKey="Matsui, M" uniqKey="Matsui M">M Matsui</name></author><author><name sortKey="Nagatani, A" uniqKey="Nagatani A">A Nagatani</name></author><author><name sortKey="Kokubu, F" uniqKey="Kokubu F">F Kokubu</name></author><author><name sortKey="Kogo, M" uniqKey="Kogo M">M Kogo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, Yn" uniqKey="Kim Y">YN Kim</name></author><author><name sortKey="Choe, Sr" uniqKey="Choe S">SR Choe</name></author><author><name sortKey="Cho, Kh" uniqKey="Cho K">KH Cho</name></author><author><name sortKey="Kang, J" uniqKey="Kang J">J Kang</name></author><author><name sortKey="Park, Cg" uniqKey="Park C">CG Park</name></author><author><name sortKey="Lee, Hy" uniqKey="Lee H">HY Lee</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goncharova, Ea" uniqKey="Goncharova E">EA Goncharova</name></author><author><name sortKey="Goncharov, Da" uniqKey="Goncharov D">DA Goncharov</name></author><author><name sortKey="Fehrenbach, M" uniqKey="Fehrenbach M">M Fehrenbach</name></author><author><name sortKey="Khavin, I" uniqKey="Khavin I">I Khavin</name></author><author><name sortKey="Ducka, B" uniqKey="Ducka B">B Ducka</name></author><author><name sortKey="Hino, O" uniqKey="Hino O">O Hino</name></author><author><name sortKey="Colby, Tv" uniqKey="Colby T">TV Colby</name></author><author><name sortKey="Merrilees, Mj" uniqKey="Merrilees M">MJ Merrilees</name></author><author><name sortKey="Haczku, A" uniqKey="Haczku A">A Haczku</name></author><author><name sortKey="Albelda, Sm" uniqKey="Albelda S">SM Albelda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bordier, C" uniqKey="Bordier C">C Bordier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nguyen, Tp" uniqKey="Nguyen T">TP Nguyen</name></author><author><name sortKey="Frank, Ar" uniqKey="Frank A">AR Frank</name></author><author><name sortKey="Jewell, Jl" uniqKey="Jewell J">JL Jewell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gulhati, P" uniqKey="Gulhati P">P Gulhati</name></author><author><name sortKey="Bowen, Ka" uniqKey="Bowen K">KA Bowen</name></author><author><name sortKey="Liu, J" uniqKey="Liu J">J Liu</name></author><author><name sortKey="Stevens, Pd" uniqKey="Stevens P">PD Stevens</name></author><author><name sortKey="Rychahou, Pg" uniqKey="Rychahou P">PG Rychahou</name></author><author><name sortKey="Chen, M" uniqKey="Chen M">M Chen</name></author><author><name sortKey="Lee, Ey" uniqKey="Lee E">EY Lee</name></author><author><name sortKey="Weiss, Hl" uniqKey="Weiss H">HL Weiss</name></author><author><name sortKey="O Onnor, Kl" uniqKey="O Onnor K">KL O’Connor</name></author><author><name sortKey="Gao, T" uniqKey="Gao T">T Gao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wood, J" uniqKey="Wood J">J Wood</name></author><author><name sortKey="Bonjean, K" uniqKey="Bonjean K">K Bonjean</name></author><author><name sortKey="Ruetz, S" uniqKey="Ruetz S">S Ruetz</name></author><author><name sortKey="Bellahcene, A" uniqKey="Bellahcene A">A Bellahcène</name></author><author><name sortKey="Devy, L" uniqKey="Devy L">L Devy</name></author><author><name sortKey="Foidart, Jm" uniqKey="Foidart J">JM Foidart</name></author><author><name sortKey="Castronovo, V" uniqKey="Castronovo V">V Castronovo</name></author><author><name sortKey="Green, Jr" uniqKey="Green J">JR Green</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dill, Pe" uniqKey="Dill P">PE Dill</name></author><author><name sortKey="Liang, N" uniqKey="Liang N">N Liang</name></author><author><name sortKey="Pende, M" uniqKey="Pende M">M Pende</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Sorrentino, G" uniqKey="Sorrentino G">G Sorrentino</name></author><author><name sortKey="Ruggeri, N" uniqKey="Ruggeri N">N Ruggeri</name></author><author><name sortKey="Specchia, V" uniqKey="Specchia V">V Specchia</name></author><author><name sortKey="Cordenonsi, M" uniqKey="Cordenonsi M">M Cordenonsi</name></author><author><name sortKey="Mano, M" uniqKey="Mano M">M Mano</name></author><author><name sortKey="Dupont, S" uniqKey="Dupont S">S Dupont</name></author><author><name sortKey="Manfrin, A" uniqKey="Manfrin A">A Manfrin</name></author><author><name sortKey="Ingallina, E" uniqKey="Ingallina E">E Ingallina</name></author><author><name sortKey="Sommaggio, R" uniqKey="Sommaggio R">R Sommaggio</name></author><author><name sortKey="Piazza, S" uniqKey="Piazza S">S Piazza</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kubista, B" uniqKey="Kubista B">B Kubista</name></author><author><name sortKey="Trieb, K" uniqKey="Trieb K">K Trieb</name></author><author><name sortKey="Sevelda, F" uniqKey="Sevelda F">F Sevelda</name></author><author><name sortKey="Toma, C" uniqKey="Toma C">C Toma</name></author><author><name sortKey="Arrich, F" uniqKey="Arrich F">F Arrich</name></author><author><name sortKey="Heffeter, P" uniqKey="Heffeter P">P Heffeter</name></author><author><name sortKey="Elbling, L" uniqKey="Elbling L">L Elbling</name></author><author><name sortKey="Sutterluty, H" uniqKey="Sutterluty H">H Sutterlüty</name></author><author><name sortKey="Scotlandi, K" uniqKey="Scotlandi K">K Scotlandi</name></author><author><name sortKey="Kotz, R" uniqKey="Kotz R">R Kotz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, Xiaolin" sort="Chen, Xiaolin" uniqKey="Chen X" first="Xiaolin" last="Chen">Xiaolin Chen</name><name sortKey="Cheng, Qi" sort="Cheng, Qi" uniqKey="Cheng Q" first="Qi" last="Cheng">Qi Cheng</name><name sortKey="Gao, Jianpu" sort="Gao, Jianpu" uniqKey="Gao J" first="Jianpu" last="Gao">Jianpu Gao</name><name sortKey="Li, Chaojun" sort="Li, Chaojun" uniqKey="Li C" first="Chaojun" last="Li">Chaojun Li</name><name sortKey="Shao, Wei" sort="Shao, Wei" uniqKey="Shao W" first="Wei" last="Shao">Wei Shao</name><name sortKey="Shao, Xiaoyan" sort="Shao, Xiaoyan" uniqKey="Shao X" first="Xiaoyan" last="Shao">Xiaoyan Shao</name><name sortKey="Wu, Jing" sort="Wu, Jing" uniqKey="Wu J" first="Jing" last="Wu">Jing Wu</name><name sortKey="Xue, Bin" sort="Xue, Bin" uniqKey="Xue B" first="Bin" last="Xue">Bin Xue</name><name sortKey="Ye, Juan" sort="Ye, Juan" uniqKey="Ye J" first="Juan" last="Ye">Juan Ye</name><name sortKey="Yuan, Xianwen" sort="Yuan, Xianwen" uniqKey="Yuan X" first="Xianwen" last="Yuan">Xianwen Yuan</name><name sortKey="Zhao, Dandan" sort="Zhao, Dandan" uniqKey="Zhao D" first="Dandan" last="Zhao">Dandan Zhao</name><name sortKey="Zhao, Yinjuan" sort="Zhao, Yinjuan" uniqKey="Zhao Y" first="Yinjuan" last="Zhao">Yinjuan Zhao</name><name sortKey="Zhao, Yue" sort="Zhao, Yue" uniqKey="Zhao Y" first="Yue" last="Zhao">Yue Zhao</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Jin, Meiling" sort="Jin, Meiling" uniqKey="Jin M" first="Meiling" last="Jin">Meiling Jin</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000009 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000009 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:7011352
|texte= Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32063747" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ChloroquineV1
| This area was generated with Dilib version V0.6.33. |  |